姓名:寇晓娣

性别:女

出生年月:1974.11

职称:教授

学历:博士

教育经历： 

2000-08至2007-08，美国德克萨斯基督教大学，化学系，博士，导师：Tracy A Hanna教授

1997-09至2000-07，南开大学，高分子化学，硕士，导师：朱常英教授

1993-09至1997-06，天津大学，高分子材料，学士 

科研与学术工作经历： 

2012-06至现在，天津中医药大学，中药学院，教授

2007-11至2011-07，美国德克萨斯大学，博士后研究员，导师：Rasika Dias 教授

教授课程：

有机化学，基础化学（合作办学），有机化学实验，杂环化学 

教学成果：

天津市本科一流课程负责人，主编教材1部， 参编多部。完成校级重点教改课题一项。指导学生完成多项国家级和天津市级创新创业项目。指导学生获得多次优秀毕业论文奖。

科研成果：

主持中西医结合重点项目一项，主持完成天津市自然科学基金一项。参与国家自然科学基金一项。近五年以第一作者或通讯作者发表 SCI 收录论文二十余篇。获批专利两项。

近期代表作：

(1) Chen QZ, Li XY, Xiao WT, Sun YY, Shen R*, Kou XD*, Yang AH*. Design, synthesis, biological evaluation and X-ray single crystal structure of novel CADD-based α-mangostin derivatives: Multifunctional ligands against Alzheimer's disease, Arch. Pharm., 2025, DOI: 10.1002/ardp.202400671

(2) Zou XY, Xiao WT, Zhou X, Shen R*, Yang AH*, Kou XD*, An insight into porphyrin carbamate derivatives and a Cu(II) metalloporphyrin as G-quadruplex binder: Synthesis, single crystal characterization, binding ability and anti-tumor potential, J. Inorg. Biochem., 2025, 269, 112901.

(3) Xiao WT, Zou XY, Zhang LJ, Shen R*, Yang AH*, Kou XD*, The new multidrug crystal of berberine and naringenin based on the couplet medicine of TCM: Crystal structure, physicochemical property, and synergistic anti-AD effect, J. Mol. Struct. 2025, 1327, 141268.

(4) Yang AH, Yi XY, Zhang HW, Chen QZ, Shen R*, Kou XD*, Study of multifunctional antiAD ligands: design, synthesis, Xray crystal structure and biological evaluation of diosmetin derivatives. Mol. Divers., 2024, Jun. 27. doi.org/10.1007/s11030-024-10913-w.

(5) Yang AH, Yi XY, Zhang HW, Shen R*, Kou XD*, Diosmetin derivatives as multifunctional anti-AD ligands: Design, synthesis, and biological evaluation. Chem Biol Drug Des. 2024, 103:e14529.

(6) Kou XD, Hu CT, Pang Z, Zhang XY, Wang HY, Shen R*, Yang AH*, A coumarin-based multifunctional chemosensor for Cu²⁺/Al³⁺ as an AD theranostic agent: Synthesis, X-ray single crystal analysis and activity study, Anal. Chim. Acta, 2023, 1279, 341818.

(7) Shen R, Chen YH, Li XY, Wang X, Yang AH*, Kou XD*, Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent, Int. J. Pharm., 2023, 630, 122458.

(8) Liu C, Wu JH, Hu CT, Yang AH*, Shen R*, Kou XD*, Synthesis, single crystal characterization and anti-AD activities of a novel complex of Cu(II) with in situ formed protonated chrysin derivative ligand, J. Inorg. Biochem., 2023, 239, 112086.

(9) Kou XD, Shi XL, Pang Z, Yang AH*, Shen R*, Zhao LH*, A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target anti-AD Theranostic Agents, Curr. Med. Chem., 2023. doi: 10.2174/0929867330666230125153027.

(10) Shen R, Zhao WS, Li XY, Liu JJ, Yang AH*, Kou XD*, Emodin derivatives as promising multi‑aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection, Mol. Divers., 2023, DOI: 10.1007/s11030-023-10733-4.

(11) Kou XD, Li XY, Hu CT, Liu JJ, Chen YH, Zhang Y, Yang AH*, Shen R*, Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease, Spectrochim. Acta A Mol. Biomol. Spectrosc., 2022, 267, 120587.

(12) Yang AH, Liu C, Zhang HW, Wu JH, Shen R*, Kou XD*, A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives, Eur. J. Med. Chem., 2022, 233, 114216.