杨爱红，汉族，中共党员，化学博士，教授，硕士生导师。毕业于天津大学，博士学位，现任天津中医药大学中药学院专任教师。

主要从事基于中药配位化学的中药活性成分发现及新药开发研究。主讲中外合作办学班的《基础化学》及中药学专业的《无机化学》等课程。主持国家自然科学基金1项、教育部中药学博士点课题1项、中国博士后基金项目1项。以第一作者或通讯作者发表SCI论文40余篇。主编或参编规划教材10余部。

承担科研项目情况：

(1) 国家自然科学基金，青年项目，81503462，基于配位理论的细辛肝毒性成分早期发现及其机理研究，已结题，主持。

(2) 中国博士后科学基金，面上项目，2014M551039，细辛潜在肝毒性成分导致CYPs不可逆抑制的配位机理研究，已结题，主持。

(3) 高等学校博士学科点专项科研基金，20121210120016，木犀草素金属配合物抗氧化清除自由基测试筛查及构效关系研究，已结题，主持。

近五年主要代表性成果：

(1) Chen QZ, Li XY, Xiao WT, Sun YY, Shen R*, Kou XD*, Yang AH*. Design, synthesis, biological evaluation and X-ray single crystal structure of novel CADD-based α-mangostin derivatives: Multifunctional ligands against Alzheimer's disease, Arch. Pharm., 2025, DOI: 10.1002/ardp.202400671.

(2) Zou XY, Xiao WT, Zhou X, Shen R*, Yang AH*, Kou XD*, An insight into porphyrin carbamate derivatives and a Cu(II) metalloporphyrin as G-quadruplex binder: Synthesis, single crystal characterization, binding ability and anti-tumor potential, J. Inorg. Biochem., 2025, 269, 112901.

(3) Yang AH, Yi XY, Zhang HW, Chen QZ, Shen R*, Kou XD*, Study of multifunctional antiAD ligands: design, synthesis, Xray crystal structure and biological evaluation of diosmetin derivatives. Mol. Divers., 2024, Jun. 27. doi.org/10.1007/s11030-024-10913-w.

(4) Kou XD, Hu CT, Pang Z, Zhang XY, Wang HY, Shen R*, Yang AH*, A coumarin-based multifunctional chemosensor for Cu²⁺/Al³⁺ as an AD theranostic agent: Synthesis, X-ray single crystal analysis and activity study, Anal. Chim. Acta, 2023, 1279, 341818.

(5) Shen R, Chen YH, Li XY, Wang X, Yang AH*, Kou XD*, Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal fr amework as a synergistic anti-AD agent, Int. J. Pharm., 2023, 630, 122458.

(6) Liu C, Wu JH, Hu CT, Yang AH*, Shen R*, Kou XD*, Synthesis, single crystal characterization and anti-AD activities of a novel complex of Cu(II) with in situ formed protonated chrysin derivative ligand, J. Inorg. Biochem., 2023, 239, 112086.

(7) Yang AH, Liu C, Zhang HW, Wu JH, Shen R*, Kou XD*, A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives, Eur. J. Med. Chem., 2022, 233, 114216.

(8) Kou XD, Li XY, Hu CT, Liu JJ, Chen YH, Zhang Y, Yang AH*, Shen R*, Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease, Spectrochim. Acta A Mol. Biomol. Spectrosc., 2022, 267, 120587.

(9) Yang AH, Liu C, Wu JR, Kou XD*, Shen R*, A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer’s disease, Eur. J. Pharmacol., 2021, 897, 173950.

(10) Liu C^#, Kou XD^#, Wang X, Wu JH, Yang AH*, Shen R*, Novel chrysin derivatives as hidden multifunctional agents for anti-Alzheimer's disease: design, synthesis and in vitro evaluation, Eur. J. Pharm. Sci., 2021, 166, 105976.

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